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bd40bc7c7a The present study aimed to verify the potential anti-inflammatory effect of galantamine against experimental arthritis induced in rats. Citing articles (0) This article has not been cited. Some suggestions: Go back to the last page Go to the home page .. Arthritis was induced by injecting 0.1ml of Complete Freund’s Adjuvant in left paw of each rat. El-Abhard, , a Department of Pharmacology, Faculty of Pharmacy and Drug Manufacturing, Pharos University, Alexandria, Egyptb Department of Pharmacology, Medical Research Institute, University of Alexandria, Alexandria, Egyptc Department of Radiology, Medical Research Institute, University of Alexandria, Alexandria, Egyptd Department of Pharmacology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, EgyptReceived 19 April 2015, Revised 25 June 2015, Accepted 15 July 2015, Available online 17 July 2015AbstractStimulation of the vagus nerve suppresses cytokine production and macrophage activation, via the interaction of its neurotransmitter acetylcholine (ACh) with the 7 subunit of the nicotinic acetylcholine receptor (7nAChR), present on neurons and inflammatory cells. In conclusion, these results suggest that galantamine may represent a novel, inexpensive and effective therapeutic strategy in the treatment of rheumatoid arthritis.Chemical compounds studied in this articleGalantamine (PubChem CID: 9651); Leflunamide (PubChem CID: 3899); Saline (PubChem CID: 5234)KeywordsAdjuvant-induced arthritis; Galantamine; Anti-CCP; TNF-; IL-10; MCP-1Corresponding author.Copyright 2015 Elsevier B.V. description The requested resource is not available.